Jackson Laboratories, Bar Harbour, Maine, USA. 10th – 12th October 2008
At this workshop several topics were discussed: the first set of results from the two arms of the ISCI2 project, defined media and genetic stability; the ISCI registry and future directions for the ISCI project to pursue.
On the first day detailed results from the media study were presented and discussed and in particular the difficulties associated with growing cells in the media formulation derived from the literature as opposed to commercial preparations. Early experimental results from the project assessing media components being conducted by Peter Zandstra.
Delegates discussed what future directions the ISCI project could go in. Several future projects were suggested including analysis of differentiation, alternatives to teratoma assays, similarities between hES and hIPS cells and proteomic analyses. Whilst no firm conclusions were reached the group felt it was important not to be too technology driven, do things that answer real biological questions and tackle manageable projects and not to try to solve all the questions in one go.
On day two the first results from the genetic stability component of ISCI2 were discussed. Detailed preliminary results from the karyotyping, methylation and SNP analyses were presented and discussed.
Agenda for International Stem Cell Initiative – 10th Anniversary Symposium
To Celebrate the Isolation of Human Embryonic Stem Cells
October 13th, 2008, The Jackson Laboratory, Bar Harbor Maine
- 7:30 – 8:00 Transportation from the Bar Harbor Regency to the Jackson Laboratory
- 8:15 Welcome (Barbara Knowles, Ph.D., The Jackson Laboratory)
Session I: Clinical Applications
- 8:30 Stemming vision loss with stem cells – seeing is believing (Peter Coffey, D.Phil., University College London)
- 9:00 Developments towards clinical applications after ten years of hESC research (Benjamin Reubinoff, M.D., Ph.D., Hadassah University Medical Center)
- 9:30 Scaled Production of High Purity Clinical Grade Motor Neurons from Human Embryonic Stem Cells (Hans Keirstead, Ph.D., University of California, Irvine)
- 10:00 Human embryonic stem cells as a system to study human genetic disorders (NissimBenvenisty, Ph.D., The Hebrew University of Jerusalem)
- 10:30 Break
Session II: Development and Pluripotency
- 11:00 Embryonic stem cells: historical perspectives (DavorSolter, M.D., Ph.D., IMB A*STAR, Singapore)
- 11:30 Engineering embryonic stem cell self-renewal and differentiation (Peter Zandstra, Ph.D., University of Toronto)
- 12:00 Stem cells and lineage development (Janet Rossant, Ph.D., University of Toronto)
- 12:30 Lunch
- 1:30 Stem cells, pluripotency and nuclear reprogramming (Rudolph Jaenisch, Ph.D., Whitehead Institute)
- 2:00 Population dynamics in human ES cell cultures: adaptaion and cancer (Peter Andrews, Ph.D., University of Sheffield)
- 2:30 Altered States of Pluripotency (Martin Pera, Ph.D., University of Southern California)
- 3:00 Break
Session III: Directed Differentiation
- 3:30 Directed differentiation and genetic modification of human embryonic stem cells (Andrew Elefanty, B.S., Ph.D., FRACP, MB, Monash University)
- 4:00 Cardiomyocytes from human embryonic stem cells in therapy and disease (Christine Mummery, Ph.D., Leiden University Medical Center)
- 4:30 Regulation of endoderm differentiation in human embryonic stem cells (MeriFirpo, Ph.D., University of Minnesota)
- 5:00 Approach Human Biology via Embryonic Stem Cells (Su Chun Zhang, M.D., Ph.D., University of Wisconsin)
- 5:30 Unique characteristics of hemato-lymphoid cell development from human ES cells (Dan Kaufman, M.D., Ph.D., University of Minnesota)