Updated November 2014
Department of Biotechnology (DBT), Ministry of Science and Technology, New Delhi, India
To create tools and technologies that address the problems of the largest section of the society, provide products and services at affordable prices and make India globally competitive in the emerging bio-economy. Policies that foster a balance between sustaining innovation and facilitating technology diffusion need to be put in place.
The Department of Biotechnology is one of the Departments under Ministry of Science and Technology, Government of India.
The membership fee will be borne by the Department of Biotechnology as per the rules of Government of India.
Annual Research Budget
Approx $280 Million
Stem Cell Budget
The budget of stem cell research and regenerative medicine is part of the Medical Biotechnology Department budget
Stem Cell Strategy
Strategy for stem cell research has been classified under two categories.
- Short-term strategy includes: thorough basic research; explore full potential of adult stem cells; generation of hESC lines; reprogramming of adult stem cells; hESCs for screening & toxicity study; to generate & characterize iPSCs; Creation of animal models for safety and efficacy study and generation of well trained HR.
- Medium & long-term strategy includes differentiation of ESCs and iPSCs into different lineages and their potential future applications; to generate disease specific cell lines; pilot studies & randomized clinical trials; building partnership with industries; capacity building in institutions and medical schools; repositories for SCs and cell lines and establish global partnership.
Key Stem Cell Centres/Investments
Institute for Stem Cell Science and Regenerative Medicine, Bangalore, Karnataka, India
The institute for Stem Cell Science and Regenerative Medicine is an autonomous institute of the Department of Biotechnology, Ministry of Science and technology, Government of India at Bangalore. The primary objective of this institute is to create an organizational structure that promotes growth of expertise in stem cell research by fostering interactions among basic scientists and clinicians in ways that support innovative research to overcome impediments to progress in the therapeutic use of human stem cells.
Centre for Stem Cell Research, Christian Medical College, Vellore, TamilNadu, India
The Centre for Stem Cell Research, CMC, Vellore is a translational unit of institute for Stem Cell Science and Regenerative Medicine, Bangalore. The major programmes of the Centres are: vascular biology and tissue engineering, gene therapy, induced-pluripotent stem cells, hematopoietic stem cell niche, etc. This Centre has also developed several national and international collaborative programmes with the clinicians and research scientists on various aspects of stem cells and regenerative medicine.
Recent Research Achievements and Outputs
Research Programmes and Policy
- Programmes are being implemented on various aspects of embryonic, adult and induced pluripotent stem cells; pre-clinical and clinical research;
- A few human ESC lines have been generated by the scientists in the country. Two cell lines have been deposited in UK Stem Cell Bank. These cell lines are being used by the national and international researchers for research purposes
- A separate Task Force on “Stem Cell Research and Regenerative Medicine” is in place to consider the proposals on their scientific merits;
- A system has been created to establish processes to consider clinical research protocol, review and monitor the human studies;
- “Guidelines for Stem Cell Research” has been revised jointly by the Department of Biotechnology, Ministry of Science & Technology and Indian Council for Medical Research, Department of Health Research, Ministry of Health & Family Welfare, Government of India;
- National Apex Committee for Stem Cell Research and Therapy (NAC-SCRT) has been established by the Government of India.
- Goodell MA. Parental Permissions: H19 and Keeping the Stem Cell Progeny under Control. Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence. Venkatraman A, Xi C. He, Joanne L. Thorvaldsen, Ryohichi Sugimura, John M. Perry, Fang Tao, Meng Zhao, Matthew K. Christenson, Rebeca Sanchez,, Jaclyn Y. Yu, Lai Peng, Jeffrey Haug, Ariel Paulson, Hua Li, Xiao-bo Zhong, Thomas L. Clemens, Marisa S. Bartolomei & Linheng Li. Nature. 2013; 500:345-349. Featured in: Cell Stem Cell. 2013;13:137-138.
- ARF1-GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis. Rohan J. Khadilkar, Diana Rodrigues, Ridim D. Mote, Arghyashree Roychowdhury Sinha, Vani Kulkarni, Magadi Srivathsa Subramanya, and Maneesha S. Inamdar*. Natl. Acad. Sci. (USA) 2014 111: 4898-4903.
- Nanofibrous gelatin substrates for long-term expansion of human pluripotent stem cells. Liu, L., Yoshioka, M., Nakajima, M., Ogasawara, A., Liu, J., Hasegawa, K., Li, S., Zou, J., Nakatsuji, N., Kamei, K. and Chen, Y. (2014). Biomaterials, 35(24) 6259-6267.
- Myotube formation on gelatin nanofibers-multiwalled carbon nanotubes hybrid scaffolds. Ostrovidov, X. Shi, L. Zhang, X. Liang, S. B. Kim, T. Fujie, R. Murugan, M. Chen, K. Nakajima, F. Al-Hazmi, H. Bae, A. Memic and A. Khademhosseini. Biomaterials 35 (2014) 6268-6277.
- Applications of carbon nanotubes in stem cell research. J. Ramón-Azcón, S. Ahadian, R. Obregon, H. Shiku, R. Murugan and T. Matsue. J. Biomed. Nanotech. 10 (2014) 2539-2561
- Coordinate hyperactivation of Notch1 and Ras/MAPK pathways correlates with poor patient survival: Novel therapeutic strategy for aggressive breast cancers. Mittal S, Sharma A, Balaji SA, Gowda MC, Dighe RR, Kumar RV, Rangarajan A.. Mol Cancer Ther. 2014 Sep 24. pii: molcanther.0280.2014.
- Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells. Hindupur SK, Balaji AS, Saxena M, Pandey S, Sravan GS, Heda N, Kumar MV, Mukherjee G, Dey D, and Rangarajan A. Breast Cancer Research 2014 Aug 6;16(4):420.
- Basic biology of Adeno-associated virus (AAV) vectors used in gene therapy. Current Gene Therapy, Volume 14, Number 2, April 2014, pp. 86-100.Balakrishnan B, Jayandharan GR.
- MyosinV aassociates with mRNA in ribo nucleoprotein particles present in myelinated peripheral axons and in the central nervous system. Calliari,,Farías,J.,Puppo,A.,Canclini,L.,Mercer,J.A.,Munroe,D.,Sotelo,J.R.,& Sotelo-Silveira, J.R.(2014) Dev Neurobiol 74:382-96.
- Stem cells in Neurological Diseases: Indian perspective. Ashu Bhasin, Padma Srivastava MV, Rohit Bhatia, Senthil Kumaran, Sujata Mohanty. J Stem Cell Res Ther 2014, 4:175.
New Funding Initiatives
New programmes have been implemented on various aspects of adult, embryonic, and induced pluripotent stem cells; developing animal models; pre-clinical; and clinical studies.
Changes to Stem Cell Related Policies
Revision of the Guidelines for Stem Cell Research
- Guidelines for stem cell research which was formulated and finalized jointly by the Department of Biotechnology and Indian Council for Medical Research in 2007 has now been revised. Based on the comments received from various stakeholders including scientists, clinicians, industry, patient group, media, etc. during region-wise public consultation in different parts of the country. The document is being considered by the National Apex Committee for Stem Cell Research and Therapy.
- The revised version of the guidelines is available on (http://www.dbtindia.nic.in/policy/Stem_Cell_research.pdf and http://www.icmr.nic.in)
National (or regional) Stem Cell Network or Contact Point
National Apex Committee for Stem Cell Research and Therapy
The Department of Health Research, Ministry of Health and Family Welfare has constituted a National Apex Committee for Stem Cell Research and Therapy (NAC-SCRT) Committee to examine the scientific, technical, ethical, legal and social issues in the area of stem cell based research and therapy. All institutions in India involved in any type of stem cell research shall be registered with the NAC-SCRT through its Institutional Committee for Stem Cell Research.
Other Major Funders of Stem Cell Research
- Indian Council of Medical Research, New Delhi – www.icmr.nic.in
- Department of Science and Technology, Ministry of Science and Technology, Government of India – www.dst.gov.in
- Council of Scientific and Industrial Research, New Delhi – www.csir.res.in
- Institute for Stem Cell Science and Regenerative Medicine, Bangalore, Karnataka, India – www.instem.res.in
- Centre for Stem Cell Research, Christian Medical College, Vellore, TamilNadu, India: www.cscr.in
- Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka – www.jncasr.ac.in
- National Centre for Cell Science, Pune – www.nccs.res.in
- All India Institute of Medical Sciences, New Delhi – www.aiims.edu
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